
研究事業

研究所概要
KTRCは主に「薬物動態学」「有機合成」「製剤」「薬剤師教育」の
4分野を専門とする研究員によって構成されています。
研究事業の主な内容は以下の通りです。
・医薬品、医薬部外品、医療用具、工業薬品、その他の薬品、
健康食品、食品添加物、飼料添加物、動植物抽出物などの天然物等の研究及び開発の受託
・医薬品開発及び医療関連事業に関するコンサルティング業務
・臨床試験支援
・セミナー、講演会、学会、研究会等の企画運営
・薬局、薬店の設立運営
研究設備
主な研究施設
In vitro実験施設、TDM室、LCMS測定室他
主な使用機器

研究実績
研究実績
K. Mizoi, R. Okada, A. Mashimo, N. Masuda, M. Itoh, S. Ishida, D. Yamazaki, T. Ogihara : Novel Screening System for Biliary Excretion of Drugs Using Human Cholangiocyte Organoid Monolayers with Directional Drug Transport, Biol. Pharm. Bull., 47, 427-433(2024).
大石時子, 佐藤初美, 木村由利絵, 吉田千草, 茂木佐智子, 柳原真知子, 山口さつき, 稲垣尚恵, 木村五月, 荻原琢男 : A.A.TH線維のアンダーウエア着用による月経随伴症状の軽減効果-ランダム化二重盲検法による検討-, 日本母子看護学会誌, 17(2), 23-33(2024).
W. Liu, X. Zhang, H. Sunakawa, L. M. B. Perera, L. Martha, K. Mizoi, T. Ogihara : Mechanism of Induction of P-gp Activity During MET Induced by DEX in Lung Cancer Cell Line. J. Pharm. Sci., 113(6), 1674-1681(2024).
H. Morishita, L. M. B. Perera, H. Sunakawa, S. Kimura, H. Yoshida, T. Ogihara : P-Glycoprotein-Mediated Interaction Is a Risk Factor for QT Prolongation in Concomitant Use of Antipsychotics and SSRIs as P-Glycoprotein-Mediated Inhibitors : Analysis of the Japanese Adverse Drug Event Report Database, J. Clin. Pharmacol., 64(1), 118-124(2024).
X. Zhang, M. Kaneko, W. Liu, O. A. Stephen, K. Yamaguchi, C. Yoshida, T. Oishi, S. Kobayashi, K. Mizoi, T. Ogihara : Analysis of protein Digestion and Absorption Using a Ussing Chamber to Simulate the Environment in the Digestive Tract, J.nutr .Sci. vitaminol., 70, 158-163(2024).
L. Manosika, B. Perera, K. Okazaki, Y. Woo, S. Takahashi, X. Zhang, K. Mizoi, T. Takahashi, T. Ogihara : Clinical Analysis and in Vitro Correlation of BCRP-Mediated Drug-Drug Interaction in the Gastrointestinal Tract, Biol. Pharm. Bull., 47(4), 750-757(2024).
H. Sunakawa, K. Mizoi, R. Takahashi, S. Takahashi, T. Ogihara : Impact of P-Glycoprotein-Mediated Drug-Endogenous Substrate Interactions on Androgen and Blood-Brain Barrier Permeability, J. Pharm. Sci., 113(1), 228-234(2024).
荻原琢男, 岡田遼 : 薬物の胆汁排泄とその評価系の最前線, YAKUGAKU ZASSHI, 145(6), 491-499(2025).
Y. Namiki, R. Sasaki, Y. Homma, K. Ida, C. Miyajima, F. Kasahara, T. Ogihara : Suppressive Effect of Calcium Alginate on Postprandial Blood Triglyceride Elevation in Rats, Jpn. Pharmacol. Ther., 53(5), 389-394(2025).
K. Yano, Y. Iwase, T. Ogihara, T. Kuwabara : Continuous exposure to therapeutic drugs doxorubicin and vincristine reduces drug efficacy through transcriptional and post-transcriptional regulation of P-glycoprotein in follicular lymphoma, Drug Metab. Pharmacokinet., 63(101495), (2025).
Y. Namiki, S. Kimura, R. Sasaki, Y. Homma, C. Miyajima, F. Kasahara, A. Kuwabara, T. Ogihara : Effect of Calcium Alginate on the Suppression of Postprandial Elevation of Serum Triglyceride Level in Humans —A Placebo-Controlled, Randomized, Double-Blind, Crossover Study, J. nutr. Sci. vitaminol., 71, 467-473(2025).
T. Fujita, Y. Kamikozawa, M. Ozawa, Y. Tajima, T. Kurosawa, Y. Katagiri, H. Kawaguchi, A. Kakuuchi, R. Miyamoto, K. Wakayama, M. Nagai, T. Taguchi, K.Bessho, D. Watanabe, T. Ogihara, H. Kusuhara, Y. Deguchi : Intracerebral Distribution of Drugs with Diverse Blood–brain Barrier Transport Characteristics: In vivo Analysis using Brain Microdialysis in Cynomolgus Monkeys, Pharmaceutical Research, 43(2)357-371(2026).
T. Hariba, K. Mizoi, S. Takahashi, H. Sunakawa, Y. Sai, J. Furumiya, M. Zuka, T. Ogihara : Analysis of blood-brain barrier permeability of drugs using forensically obtained human cerebrospinal fluid and plasma in Japan, Drug Metab. Pharmacokinet., 66(101507), (2026).
W. Liu, M. Yajima, T. Hariba, H. Sunakawa, K. Yano, K. Mizoi, T. Ogihara : Role of P-Glycoprotein Expression and Scaffold Proteins in the Entire Metastasis Process in Lung Cancer Cell Lines, Biol. Phorm. Bull., 49(3), 513-519(2026).
Y. Kurobe-Takashima, K. Yanagisawa, Y. Saito, R. Miyawaki, T. Misaka, J. Mizoi, E. Miyauchi, N. Sasaki, T. Ogihara, S. Kobayashi : Contribution of organic anion transporting polypeptides to bile acid uptake in the Caco-2 cell monolayer and gastrointestinal tract, J. Biol. Chem., 302(3), 111205(2026).
Y. Namiki, K. Ida, Y. Homma, N. Tomimori, K. Sato, C. Kakinuma, H. Tachiki, T. Ogihara : Investigation of the Effects of Calcium Alginate on Blood Sodium Concentration and the Suppression of Blood Pressure Elevation in Rats, Biol. Phorm. Bull., 49(3), 564-579(2026).
受託実績
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製剤服用性アンケート
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食品成分の機能性評価
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特定保健用食品の臨床試験
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新規医療品の溶解性改善
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新規医療品の製剤化検討
